From Milan follow the signs for the A9 motorway, connecting Milan to Switzerland, direction Como - Chiasso.
Take the exit Lago di Como (last exit before the Swiss border coming from Milan; first exit after the Swiss border coming from Switzerland).
And then direction to Colico , take the main road that runs along the lake ( Regina road ).
The closest train station is Como San Giovanni (only 30 km away) From Milano Centrale trainstation and Milan Porta Garibaldi train station, trains to Como S. Giovanni station leave approximately every hour.
Then you can take the boat service updated timetables and tickets online purchasing available on the website www.trenitalia.com , by bus take the C10 in direction to Colico or we can organize for you a private transfer by taxi ( contact the hotel reception )
The most convenient Italian International Airports to reach Grand Hotel Cadenabbia**** on Lake Como are Milan Malpensa (80 km away - 55 minutes driving) and at Milan Linate (95 km away - 1,20 hours driving), as well as Bergamo Orio Al Serio (120 km away - 1,45 hours driving).